On the Increased and Decreased Connectivity of the Demented Human Brain

With the enormous advances in cerebral imaging techniques, a large amount of data is available for studying the aging and demented brain. In this contribution, we apply the OASIS-3 dataset for identifying small areas of the human gray matter, which have higher- or lower structural connectivity in dementia and aging. As anticipated, we found that finer structures of the hippocampus and the temporal lobe show decreased connectivity in dementia. More surprisingly, the precuneus, the cuneus, and finer structures in the insula show higher connectivity in dementia than in the healthy state.