{"ID":2898609,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2507.02345","arxiv_id":"2507.02345","title":"HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3","abstract":"Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive experimental screening. To enhance and streamline this process, we introduce a production-grade, high-throughput platform built on HelixFold3, HelixDesign-Antibody, which utilizes the high-accuracy structure prediction model, HelixFold3. The platform facilitates the large-scale generation of antibody candidate sequences and evaluates their interaction with antigens. Integrated high-performance computing (HPC) support enables high-throughput screening, addressing challenges such as fragmented toolchains and high computational demands. Validation on multiple antigens showcases the platform's ability to generate diverse and high-quality antibodies, confirming a scaling law where exploring larger sequence spaces increases the likelihood of identifying optimal binders. This platform provides a seamless, accessible solution for large-scale antibody design and is available via the antibody design page of PaddleHelix platform.","short_abstract":"Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive experimental screening. To enhance and streamline this process, we introduce a production-grade, high-throughput platform built on HelixFold3...","url_abs":"https://arxiv.org/abs/2507.02345","url_pdf":"https://arxiv.org/pdf/2507.02345v1","authors":"[\"Jie Gao\",\"Jing Hu\",\"Shanzhuo Zhang\",\"Kunrui Zhu\",\"Sheng Qian\",\"Yueyang Huang\",\"Xiaonan Zhang\",\"Xiaomin Fang\"]","published":"2025-07-03T06:13:23Z","proceeding":"q-bio.BM","tasks":"[\"q-bio.BM\",\"cs.AI\"]","methods":"[]","has_code":false}