{"ID":2875786,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2509.01214","arxiv_id":"2509.01214","title":"PRINTER:Deformation-Aware Adversarial Learning for Virtual IHC Staining with In Situ Fidelity","abstract":"Tumor spatial heterogeneity analysis requires precise correlation between Hematoxylin and Eosin H\u0026E morphology and immunohistochemical (IHC) biomarker expression, yet current methods suffer from spatial misalignment in consecutive sections, severely compromising in situ pathological interpretation. In order to obtain a more accurate virtual staining pattern, We propose PRINTER, a weakly-supervised framework that integrates PRototype-drIven content and staiNing patTERn decoupling and deformation-aware adversarial learning strategies designed to accurately learn IHC staining patterns while preserving H\u0026E staining details. Our approach introduces three key innovations: (1) A prototype-driven staining pattern transfer with explicit content-style decoupling; and (2) A cyclic registration-synthesis framework GapBridge that bridges H\u0026E and IHC domains through deformable structural alignment, where registered features guide cross-modal style transfer while synthesized outputs iteratively refine the registration;(3) Deformation-Aware Adversarial Learning: We propose a training framework where a generator and deformation-aware registration network jointly adversarially optimize a style-focused discriminator. Extensive experiments demonstrate that PRINTER effectively achieves superior performance in preserving H\u0026E staining details and virtual staining fidelity, outperforming state-of-the-art methods. Our work provides a robust and scalable solution for virtual staining, advancing the field of computational pathology.","short_abstract":"Tumor spatial heterogeneity analysis requires precise correlation between Hematoxylin and Eosin H\u0026E morphology and immunohistochemical (IHC) biomarker expression, yet current methods suffer from spatial misalignment in consecutive sections, severely compromising in situ pathological interpretation. In order to obtain a...","url_abs":"https://arxiv.org/abs/2509.01214","url_pdf":"https://arxiv.org/pdf/2509.01214v1","authors":"[\"Yizhe Yuan\",\"Bingsen Xue\",\"Bangzheng Pu\",\"Chengxiang Wang\",\"Cheng Jin\"]","published":"2025-09-01T07:53:05Z","proceeding":"cs.CV","tasks":"[\"cs.CV\",\"cs.MM\"]","methods":"[]","has_code":false}