{"ID":2869031,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2510.13815","arxiv_id":"2510.13815","title":"A Two-Feature Quantitative EEG Index of Pediatric Epilepsy Severity: External Pre-Validation on CHB-MIT and Roadmap to Dravet Cohorts","abstract":"Objective biomarkers for staging pediatric epileptic encephalopathies are scarce. We revisited a large open repository -- the CHB-MIT Scalp EEG Database, 22 subjects aged 1.5-19 y recorded at 256 Hz under the 10-20 montage -- to derive and validate a compact quantitative index, DS-Qi = (theta/alpha)_posterior + (1 - wPLI_beta). The first term captures excess posterior slow-wave power, a recognized marker of impaired cortical maturation; the second employs the debiased weighted Phase-Lag Index to measure loss of beta-band synchrony, robust to volume conduction and small-sample bias. In 30-min awake, eyes-open segments, DS-Qi was 1.69 +/- 0.21 in epilepsy versus 1.23 +/- 0.17 in age-matched normative EEG (Cohen's d = 1.1, p \u003c 0.001). A logistic model trained with 10 x 10-fold cross-validation yielded an AUC of 0.90 (95% CI 0.81-0.97) and optimal sensitivity/specificity of 86%/83% at DS-Qi = 1.46. Across multi-day recordings, test-retest reliability was ICC = 0.74, and higher DS-Qi correlated with greater seizure burden (rho = 0.58, p = 0.004). These results establish DS-Qi as a reproducible, single-number summary of electrophysiological severity that can be computed from short scalp EEG segments using only posterior and standard 10-20 electrodes.","short_abstract":"Objective biomarkers for staging pediatric epileptic encephalopathies are scarce. We revisited a large open repository -- the CHB-MIT Scalp EEG Database, 22 subjects aged 1.5-19 y recorded at 256 Hz under the 10-20 montage -- to derive and validate a compact quantitative index, DS-Qi = (theta/alpha)_posterior + (1 - wP...","url_abs":"https://arxiv.org/abs/2510.13815","url_pdf":"https://arxiv.org/pdf/2510.13815v1","authors":"[\"Khartik Uppalapati\",\"Bora Yimenicioglu\",\"Shakeel Abdulkareem\",\"Bhavya Uppalapati\",\"Viraj Kamath\",\"Adan Eftekhari\",\"Pranav Ayyappan\"]","published":"2025-09-19T21:12:26Z","proceeding":"q-bio.NC","tasks":"[\"q-bio.NC\"]","methods":"[]","has_code":false}