{"ID":2866277,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2509.21695","arxiv_id":"2509.21695","title":"Wav2Arrest 2.0: Long-Horizon Cardiac Arrest Prediction with Time-to-Event Modeling, Identity-Invariance, and Pseudo-Lab Alignment","abstract":"High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events, including Cardiac Arrest (CA). However, their powerful representation still needs to be leveraged suitably, especially when the downstream data/label is scarce. We offer three orthogonal improvements to improve PPG-only CA systems by using minimal auxiliary information. First, we propose to use time-to-event modeling, either through simple regression to the event onset time or by pursuing fine-grained discrete survival modeling. Second, we encourage the model to learn CA-focused features by making them patient-identity invariant. This is achieved by first training the largest-scale de-identified biometric identification model, referred to as the p-vector, and subsequently using it adversarially to deconfound cues, such as person identity, that may cause overfitting through memorization. Third, we propose regression on the pseudo-lab values generated by pre-trained auxiliary estimator networks. This is crucial since true blood lab measurements, such as lactate, sodium, troponin, and potassium, are collected sparingly. Via zero-shot prediction, the auxiliary networks can enrich cardiac arrest waveform labels and generate pseudo-continuous estimates as targets. Our proposals can independently improve the 24-hour time-averaged AUC from the 0.74 to the 0.78-0.80 range. We primarily improve over longer time horizons with minimal degradation near the event, thus pushing the Early Warning System research. Finally, we pursue multi-task formulation and diagnose it with a high gradient conflict rate among competing losses, which we alleviate via the PCGrad optimization technique.","short_abstract":"High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events, including Cardiac Arrest (CA). However, their powerful representation still need...","url_abs":"https://arxiv.org/abs/2509.21695","url_pdf":"https://arxiv.org/pdf/2509.21695v1","authors":"[\"Saurabh Kataria\",\"Davood Fattahi\",\"Minxiao Wang\",\"Ran Xiao\",\"Matthew Clark\",\"Timothy Ruchti\",\"Mark Mai\",\"Xiao Hu\"]","published":"2025-09-25T23:46:39Z","proceeding":"cs.LG","tasks":"[\"cs.LG\"]","methods":"[]","has_code":false}