{"ID":2854137,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2510.15684","arxiv_id":"2510.15684","title":"Towards Label-Free Brain Tumor Segmentation: Unsupervised Learning with Multimodal MRI","abstract":"Unsupervised anomaly detection (UAD) presents a complementary alternative to supervised learning for brain tumor segmentation in magnetic resonance imaging (MRI), particularly when annotated datasets are limited, costly, or inconsistent. In this work, we propose a novel Multimodal Vision Transformer Autoencoder (MViT-AE) trained exclusively on healthy brain MRIs to detect and localize tumors via reconstruction-based error maps. This unsupervised paradigm enables segmentation without reliance on manual labels, addressing a key scalability bottleneck in neuroimaging workflows. Our method is evaluated in the BraTS-GoAT 2025 Lighthouse dataset, which includes various types of tumors such as gliomas, meningiomas, and pediatric brain tumors. To enhance performance, we introduce a multimodal early-late fusion strategy that leverages complementary information across multiple MRI sequences, and a post-processing pipeline that integrates the Segment Anything Model (SAM) to refine predicted tumor contours. Despite the known challenges of UAD, particularly in detecting small or non-enhancing lesions, our method achieves clinically meaningful tumor localization, with lesion-wise Dice Similarity Coefficient of 0.437 (Whole Tumor), 0.316 (Tumor Core), and 0.350 (Enhancing Tumor) on the test set, and an anomaly Detection Rate of 89.4% on the validation set. These findings highlight the potential of transformer-based unsupervised models to serve as scalable, label-efficient tools for neuro-oncological imaging.","short_abstract":"Unsupervised anomaly detection (UAD) presents a complementary alternative to supervised learning for brain tumor segmentation in magnetic resonance imaging (MRI), particularly when annotated datasets are limited, costly, or inconsistent. In this work, we propose a novel Multimodal Vision Transformer Autoencoder (MViT-A...","url_abs":"https://arxiv.org/abs/2510.15684","url_pdf":"https://arxiv.org/pdf/2510.15684v1","authors":"[\"Gerard Comas-Quiles\",\"Carles Garcia-Cabrera\",\"Julia Dietlmeier\",\"Noel E. O'Connor\",\"Ferran Marques\"]","published":"2025-10-17T14:26:30Z","proceeding":"cs.CV","tasks":"[\"cs.CV\",\"cs.AI\"]","methods":"[\"Vision Transformer\",\"Transformer\"]","has_code":false}