{"ID":2845692,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2511.03263","arxiv_id":"2511.03263","title":"FAPEX: Fractional Amplitude-Phase Expressor for Robust Cross-Subject Seizure Prediction","abstract":"Precise, generalizable subject-agnostic seizure prediction (SASP) remains a fundamental challenge due to the intrinsic complexity and significant spectral variability of electrophysiological signals across individuals and recording modalities. We propose FAPEX, a novel architecture that introduces a learnable fractional neural frame operator (FrNFO) for adaptive time-frequency decomposition. Unlike conventional models that exhibit spectral bias toward low frequencies, our FrNFO employs fractional-order convolutions to capture both high and low-frequency dynamics, achieving approximately 10% improvement in F1-score and sensitivity over state-of-the-art baselines. The FrNFO enables the extraction of instantaneous phase and amplitude representations that are particularly informative for preictal biomarker discovery and enhance out-of-distribution generalization. FAPEX further integrates structural state-space modeling and channelwise attention, allowing it to handle heterogeneous electrode montages. Evaluated across 12 benchmarks spanning species (human, rat, dog, macaque) and modalities (Scalp-EEG, SEEG, ECoG, LFP), FAPEX consistently outperforms 23 supervised and 10 self-supervised baselines under nested cross-validation, with gains of up to 15% in sensitivity on complex cross-domain scenarios. It further demonstrates superior performance in several external validation cohorts. To our knowledge, these establish FAPEX as the first epilepsy model to show consistent superiority in SASP, offering a promising solution for discovering epileptic biomarker evidence supporting the existence of a distinct and identifiable preictal state and clinical translation.","short_abstract":"Precise, generalizable subject-agnostic seizure prediction (SASP) remains a fundamental challenge due to the intrinsic complexity and significant spectral variability of electrophysiological signals across individuals and recording modalities. We propose FAPEX, a novel architecture that introduces a learnable fractiona...","url_abs":"https://arxiv.org/abs/2511.03263","url_pdf":"https://arxiv.org/pdf/2511.03263v1","authors":"[\"Ruizhe Zheng\",\"Lingyan Mao\",\"Dingding Han\",\"Tian Luo\",\"Yi Wang\",\"Jing Ding\",\"Yuguo Yu\"]","published":"2025-11-05T07:49:53Z","proceeding":"q-bio.NC","tasks":"[\"q-bio.NC\",\"eess.SP\"]","methods":"[]","has_code":false}