{"ID":2840043,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2511.14466","arxiv_id":"2511.14466","title":"Effect of Dopamine in Enhancement of SNR of Cortico-Striatal-Thalamo-Cortical Loop Spiking","abstract":"In this work, the effects of dopamine neurotransmitter within the Cortico-Striatal-Thalamo-Cortical (CSTC) loop have been investigated. Simulations confirmed dopamine facilitates movement via thalamic disinhibition. Analysis of its impact on the signal-to-noise ratio (SNR) revealed a complex, region-specific outcome: SNR increased in some regions (e.g., D2 Striatum: 3.41 dB to 6.25 dB), decreased in others (e.g., Thalamus VL: 6.24 dB to 3.93 dB), and remained stable elsewhere (e.g., M1: 3.16 dB to 3.13 dB). This heterogeneity stems from dopamine increasing the excitability of D1-receptor-expressing neurons, which amplifies channel conductance noise and reduces SNR in specific circuits. Thus, dopamine acts not as a uniform signal enhancer, but as a complex modulator that critically balances facilitation and noise within the CSTC loop.","short_abstract":"In this work, the effects of dopamine neurotransmitter within the Cortico-Striatal-Thalamo-Cortical (CSTC) loop have been investigated. Simulations confirmed dopamine facilitates movement via thalamic disinhibition. Analysis of its impact on the signal-to-noise ratio (SNR) revealed a complex, region-specific outcome: S...","url_abs":"https://arxiv.org/abs/2511.14466","url_pdf":"https://arxiv.org/pdf/2511.14466v2","authors":"[\"Hadi Barati\",\"Ali Nayerifar\",\"Mehdi Fardmanesh\"]","published":"2025-11-18T13:05:09Z","proceeding":"q-bio.NC","tasks":"[\"q-bio.NC\"]","methods":"[]","has_code":false}