{"ID":2837331,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2511.19520","arxiv_id":"2511.19520","title":"Modeling Bioelectric State Transitions in Glial Cells: An ASAL-Inspired Computational Approach to Glioblastoma Initiation","abstract":"Understanding how glioblastoma (GBM) emerges from initially healthy glial tissue requires models that integrate bioelectrical, metabolic, and multicellular dynamics. This work introduces an ASAL-inspired agent-based framework that simulates bioelectric state transitions in glial cells as a function of mitochondrial efficiency (Meff), ion-channel conductances, gap-junction coupling, and ROS dynamics. Using a 64x64 multicellular grid over 60,000 simulation steps, we show that reducing Meff below a critical threshold (~0.6) drives sustained depolarization, ATP collapse, and elevated ROS, reproducing key electrophysiological signatures associated with GBM. We further apply evolutionary optimization (genetic algorithms and MAP-Elites) to explore resilience, parameter sensitivity, and the emergence of tumor-like attractors. Early evolutionary runs converge toward depolarized, ROS-dominated regimes characterized by weakened electrical coupling and altered ionic transport. These results highlight mitochondrial dysfunction and disrupted bioelectric signaling as sufficient drivers of malignant-like transitions and provide a computational basis for probing the bioelectrical origins of oncogenesis.","short_abstract":"Understanding how glioblastoma (GBM) emerges from initially healthy glial tissue requires models that integrate bioelectrical, metabolic, and multicellular dynamics. This work introduces an ASAL-inspired agent-based framework that simulates bioelectric state transitions in glial cells as a function of mitochondrial eff...","url_abs":"https://arxiv.org/abs/2511.19520","url_pdf":"https://arxiv.org/pdf/2511.19520v1","authors":"[\"Wiktoria Agata Pawlak\"]","published":"2025-11-24T04:59:51Z","proceeding":"physics.bio-ph","tasks":"[\"physics.bio-ph\",\"cs.NE\",\"q-bio.NC\"]","methods":"[]","has_code":false}