{"ID":2827580,"CreatedAt":"2026-06-01T04:54:23.091178241Z","UpdatedAt":"2026-06-01T04:54:23.091178241Z","DeletedAt":null,"paper_url":"https://arxiv.org/abs/2512.16577","arxiv_id":"2512.16577","title":"CRONOS: Continuous Time Reconstruction for 4D Medical Longitudinal Series","abstract":"Forecasting how 3D medical scans evolve over time is important for disease progression, treatment planning, and developmental assessment. Yet existing models either rely on a single prior scan, fixed grid times, or target global labels, which limits voxel-level forecasting under irregular sampling. We present CRONOS, a unified framework for many-to-one prediction from multiple past scans that supports both discrete (grid-based) and continuous (real-valued) timestamps in one model, to the best of our knowledge the first to achieve continuous sequence-to-image forecasting for 3D medical data. CRONOS learns a spatio-temporal velocity field that transports context volumes toward a target volume at an arbitrary time, while operating directly in 3D voxel space. Across three public datasets spanning Cine-MRI, perfusion CT, and longitudinal MRI, CRONOS outperforms other baselines, while remaining computationally competitive. We will release code and evaluation protocols to enable reproducible, multi-dataset benchmarking of multi-context, continuous-time forecasting.","short_abstract":"Forecasting how 3D medical scans evolve over time is important for disease progression, treatment planning, and developmental assessment. Yet existing models either rely on a single prior scan, fixed grid times, or target global labels, which limits voxel-level forecasting under irregular sampling. We present CRONOS, a...","url_abs":"https://arxiv.org/abs/2512.16577","url_pdf":"https://arxiv.org/pdf/2512.16577v1","authors":"[\"Nico Albert Disch\",\"Saikat Roy\",\"Constantin Ulrich\",\"Yannick Kirchhoff\",\"Maximilian Rokuss\",\"Robin Peretzke\",\"David Zimmerer\",\"Klaus Maier-Hein\"]","published":"2025-12-18T14:16:46Z","proceeding":"cs.CV","tasks":"[\"cs.CV\"]","methods":"[]","has_code":false}